Poor Prognosis In Breast Cancer Linked To PI3K mTOR Pathway Proteins
Four proteins involved in translation, the final step of general protein production, are associated with poor prognosis in hormone-receptor-positive breast cancer when they are dysregulated, researchers reported at the AACR Annual Meeting 2012. All of the aberrantly activated translational proteins are regulated by the PI3K/mTOR molecular signaling pathway, which has been implicated in development and progression of several cancers. More recently, mTOR activation has been tied to resistance to standard endocrine therapy in estrogen-receptor positive breast cancer, said Funda Meric-Bernstam, M.
Preparations For Possible Study Of Cancer Risks Near US Nuclear Facilities
A proposed study could help determine if there is a link between living near nuclear power plants or other nuclear facilities and having a higher risk of cancer, but challenges and limitations exist, says a new report from the National Research Council, the operating arm of the National Academy of Sciences and National Academy of Engineering. The report recommends that a pilot study be completed first to evaluate the feasibility of a full-scale study, although the ultimate decision about whether to perform either would be the responsibility of the U.
Critical Regulatory Mechanism Controlling Blood Vessel Growth Discovered That Might Help Solve Drug Resistance Problems In The Future
Angiogenesis, the growth of new blood vessels, is a complex process during which different signalling proteins interact with each other in a highly coordinated fashion. The growth factor VEGF and the Notch signalling pathway both play important roles in this process. VEGF promotes vessel growth by binding to its receptor, VEGFR2, while the Notch signalling pathway acts like a switch capable of suppressing angiogenesis. Until recently, scientists had assumed that Notch cancels the effects of VEGF through the downregulation of VEGFR2.