A Model For Collaboration - Indiana Clinical And Translational Science Institute HUB
At a time when medical research increasingly requires collaboration by large numbers of busy people, the Indiana Clinical and Translational Science Institute HUB offers a model for using advanced information technology to link scientists, health providers, community partners and others for the purpose of accelerating clinical and translational research. The Indiana CTSI HUB is a virtual, institution-scale medical research organization for Indiana, including Indiana University, Purdue University and the University of Notre Dame.
A Promising Novel Therapeutic Target In Cancer - The USP15 Biological Thermostat
After years studying the molecular bases of glioblastoma - the most common brain tumor and one of the most aggressive of all cancers, the group led by Dr. Joan Seoane, Director of Translational Research at the Vall d'Hebron Institute of Oncology (VHIO) and ICREA Research Professor has published a study in Nature Medicine identifying USP15 as a critical protein in cancer which, thanks to its molecular characteristics, shows enormous therapeutic promise. USP15 promotes tumor progression by activating the TGFО pathway.
Drug Combo Kills Pancreatic Cancer Cells
Combining gemcitabine with MRK003, an experimental drug, triggers a chain of events leading to pancreatic cancer cell death, researchers from Cambridge reported in the Journal of Experimental Medicine. The researchers explained that when the two drugs are combined, the effect of each one is multiplied, thus intensifying the destruction of pancreatic cancer cells. Professor David Tuveson, from the Cambridge Research Institute, UK, and team demonstrated in animal studies that MRK003, an experimental medication, when combined with chemotherapy medication gemcitabine, set off a domino effect which ultimately destroyed the malignant cells.